In Vitro Evaluation Of Naproxen Metabolite, O-Desmethylnaproxen On A Mouse Connective Tissue Fibroblast Cells
نویسندگان
چکیده
The aim of this in vitro study was assessment the cytotoxic level 6-O-desmethylnaproxen. A mouse connective tissue fibroblast cell line, L929 exposed to naproxen and 6-O-desmethylnaproxen different concentrations for 24- 48- hours. Cell viability tested by MTT, while apoptosis determined AO/PI double staining method. control group free from any agent (DMEM only) accepted as 100% viability. IC50 results indicated that inhibition 50% resulted highest concentration (0.7 µg/mL) none caused dead. Consequently, avoid unacceptable side effects metabolites evacuated urine; further studies should be conducted determine accumulation metabolites.
منابع مشابه
inductive effect of palatal connective tissue on alveolar mocosa after subepithelial connective tissue graft clinical & histologic study
چکیده ندارد.
15 صفحه اولEffect of Fibroblast Co-culture on In Vitro Maturation and Fertilization of Mouse Preantral Follicles
متن کامل
Fibroblast involvement in soft connective tissue calcification
Soft connective tissue calcification is not a passive process, but the consequence of metabolic changes of local mesenchymal cells that, depending on both genetic and environmental factors, alter the balance between pro- and anti-calcifying pathways. While the role of smooth muscle cells and pericytes in ectopic calcifications has been widely investigated, the involvement of fibroblasts is stil...
متن کاملEvaluation of Chronotropic Properties of Mouse Embryonic Stem Cells-Derived Cardiomyocytes After Fibroblast Growth Factor Treatment
Purpose: We investigated the effect of (bFGF) (basic-Fibroblast Growth Factor) on the differentiation of divided cardiomyocytes from mouse embryonic stem cells (ES) and their pharmacological properties. Materials and Methods: The mouse embryonic stem cells (Royan B1) were cultured as 800 cells per 20µl of a hanging drop. After two days, ES cells in each drop aggregated to form embryoid bodies ...
متن کاملI-11: Dedifferentiation of Mouse Fibroblast Cells by Chemical Induction
Induced pluripotent stem cells (iPSCs) generated by ectopic expression of four transcription factors have great promises for regenerative medicine in humans. Since the initial report of iPSCs by viral transfection, ample efforts have been made in the generation of iPSCs through nonviral approaches. Small molecules offer the advantages of low cost without genomic modification and have been used ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Hacettepe Journal of Biology and Chemistry
سال: 2021
ISSN: ['1303-5002']
DOI: https://doi.org/10.15671/hjbc.680564